![]() The major challenge is the short half-life of 99mTc, causing logistic challenges in scheduling SLN mapping (lymphoscintigraphy (LS) and single-photon emission computed tomography (SPECT/CT)) prior to the surgery. This SLN localization technique, however, is associated with several drawbacks. The current gold standard for SLN mapping is a dual tracing technique, using a Technetium ( 99mTc) tracer and Blue Dye. Previous research showed that SLN locations can be unpredictable and therefore difficult to localize without imaging. The importance of the SLNB has become even more pronounced since the introduction of adjuvant immunotherapy in stage III melanoma. Sentinel lymph node biopsy (SLNB) is an important prognostic procedure in the staging of malignant melanomas and plays a crucial role in postoperative management. Result will be used in a larger prospective study with melanoma patients. An intracutaneous injection of 1.0 ml SPIO tracer, followed by a two-minute massage seems to be the most effective technique, simplifying the pre-operative pathway. SPIO and pre-operative MRI-scanning seems to be a promising alternative for SLN visualization in melanoma patients. All SLNs were observed within five minutes, except after lower limb injection (30 min). Four participants received a 1.0 ml intracutaneous injection and two-minute massage, leading to artefacts in all participants. Two participants received a 0.5 ml subcutaneous injection and 30-s massage, of which one showed an artefact after one hour. ResultsĪrtefacts were identified in 5/6 participants. The first lymph node showing a susceptibility artefact caused by SPIO accumulation was considered as SLN. Workflow protocols varied in dosage, massage duration, route of administration and injection sites. Healthy participants underwent MRI-scanning pre- and post SPIO-injection during 20 min. Limited research has been performed on SPIO use and pre-operative MRI in melanoma patients to identify SLNs. Superparamagnetic iron oxide (SPIO) is a non-inferior alternative for SLN mapping in breast cancer patients. Current pre-operative Sentinel Lymph Node (SLN) mapping using dual tracing is associated with drawbacks (radiation exposure, logistic challenges). ![]()
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